Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pde6c. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 11, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Pde6c
  • participates in the following biological processes:
    • phototransduction, visible light ^[1]
    • retinal cone cell development ^[2]
    • sensory perception of light stimulus ^[1]

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Summary text based on GO annotations supported by structural data

• Pde6c encodes a protein or proteins that contain the following InterPro domains: 3'5'-cyclic nucleotide phosphodiesterase, 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, 3'5'-cyclic nucleotide phosphodiesterase, conserved site, GAF domain, HD/PDEase domain, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • 3',5'-cyclic-nucleotide phosphodiesterase activity
    • catalytic activity
    • phosphoric diester hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pde6c indicates that it:
  • participates in the following biological processes:
    • response to stimulus
    • visual perception
  • performs the following molecular functions:
    • cGMP binding
    • hydrolase activity
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • membrane
    • plasma membrane
• Pde6c has been associated with the Enzyme Commission numbers: 3.1.4.35, which implies that the gene product:
  • performs the following molecular functions:
    • 3',5'-cyclic-GMP phosphodiesterase activity

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References

1. Lei B et al. (2006) Study of rod- and cone-driven oscillatory potentials in mice. Invest Ophthalmol Vis Sci, 47:2732-8. (PubMed:16723493)
2. Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol, 2011:391384. (PubMed:21052544)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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