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Gene Ontology Classifications
ATPase, Ca++ transporting, plasma membrane 2

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atp2b2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 11, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Chen Z et al. (2006) A novel mutant mouse, joggle, with inherited ataxia. Exp Anim, 55:411-4. (PubMed:16880690)
  2. Dodson HC et al. (2001) PMCA2 mutation causes structural changes in the auditory system in deafwaddler mice. J Neurocytol, 30:281-92. (PubMed:11875276)
  3. Empson RM et al. (2007) Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J Neurosci, 27:3753-8. (PubMed:17409239)
  4. Ficarella R et al. (2007) A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness. Proc Natl Acad Sci U S A, 104:1516-21. (PubMed:17234811)
  5. Hunt DL et al. (2006) Multisensory plasticity in congenitally deaf mice: How are cortical areas functionally specified? Neuroscience, 139:1507-24. (PubMed:16529873)
  6. Ikeda M et al. (1994) Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami. Neurosci Lett, 168:65-8. (PubMed:7518067)
  7. Ikeda M et al. (1989) A neurochemical study of a new mutant mouse presenting myoclonus-like involuntary movement: a possible model of spontaneous serotonergic hyperactivity. Brain Res, 495:337-48. (PubMed:2765934)
  8. Inoue Y et al. (1993) Abnormal synaptic architecture in the cerebellar cortex of a new dystonic mutant mouse, Wriggle Mouse Sagami. Neurosci Res, 16:39-48. (PubMed:7683393)
  9. Kozel PJ et al. (2002) Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hear Res, 164:231-9. (PubMed:11950541)
  10. Kozel PJ et al. (1998) Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem, 273:18693-6. (PubMed:9668038)
  11. Matsui K et al. (1987) [Fundamental study on ataxic mice (wriggle mouse Sagami)] Jikken Dobutsu, 36:185-9. (PubMed:3038581)
  12. McCullough BJ et al. (2004) Haplo-insufficiency revealed in deafwaddler mice when tested for hearing loss and ataxia. Hear Res, 195:90-102. (PubMed:15350283)
  13. Noben-Trauth K et al. (1997) mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics, 44:266-72. (PubMed:9325047)
  14. Osawa N et al. (1992) New neurological mutant "wriggle mouse sagami" with an interesting movement disorder Mouse Genome, 90:223.
  15. Reinhardt TA et al. (2004) Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J Biol Chem, 279:42369-73. (PubMed:15302868)
  16. Street VA et al. (1998) Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice. Nat Genet, 19:390-4. (PubMed:9697703)
  17. Takahashi K et al. (1999) Evaluation of inner ear histology and auditory brainstem response in Wriggle Mouse Sagami. Acta Otolaryngol, 119:767-72. (PubMed:10687933)
  18. Takahashi K et al. (1999) A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse Sagami. Biochem Biophys Res Commun, 261:773-8. (PubMed:10441500)
  19. Tsai YS et al. (2006) A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. Mamm Genome, 17:716-22. (PubMed:16845470)
  20. Ueno T et al. (2002) A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons. Neurosci Res, 42:287-97. (PubMed:11985881)
  21. VanHouten JN et al. (2007) The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology, 148:5943-54. (PubMed:17823248)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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MGI 5.22
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