Automated description from the Alliance of Genome Resources (Release 8.1.0)
Enables 3-hydroxyacyl-CoA dehydratase activity and 3-hydroxyacyl-CoA dehydrogenase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Acts upstream of or within Sertoli cell development; fatty acid beta-oxidation; and very long-chain fatty acid metabolic process. Located in peroxisome. Is active in peroxisomal matrix. Is expressed in several structures, including brain; genitourinary system; hindlimb phalanx; integumental system; and jaw. Used to study D-bifunctional protein deficiency. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4).
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