Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including guanyl ribonucleotide binding activity; retromer complex binding activity; and small GTPase binding activity. Involved in lipophagy. Acts upstream of or within with a positive effect on establishment of vesicle localization. Located in several cellular components, including late endosome membrane; lipid droplet; and phagophore assembly site membrane. Is active in lysosome. Colocalizes with lysosomal membrane. Is expressed in several structures, including 1-cell stage embryo; cerebral cortex; lung mesenchyme; oocyte; and primitive endoderm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family).