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Gene Ontology Classifications
Symbol
Name
ID
Rab7
RAB7, member RAS oncogene family
MGI:105068

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rab7. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bell AW et al. (2001) Proteomics characterization of abundant Golgi membrane proteins. J Biol Chem, 276:5152-65. (PubMed:11042173)
  2. Cormont M et al. (2001) A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Proc Natl Acad Sci U S A, 98:1637-42. (PubMed:11172003)
  3. Farg MA et al. (2014) C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet, null:null. (PubMed:24549040)
  4. Fossale E et al. (2004) Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci, 5:57. (PubMed:15588329)
  5. Ha SD et al. (2012) Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol, 32:4846-60. (PubMed:23028046)
  6. Mayer PR et al. (2010) Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem, 285:40387-96. (PubMed:20943658)
  7. Mizuno K et al. (2003) Rabring7, a novel Rab7 target protein with a RING finger motif. Mol Biol Cell, 14:3741-52. (PubMed:12972561)
  8. Ohbayashi N et al. (2012) Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci, 125:1508-18. (PubMed:22275436)
  9. Ouyang Q et al. (2013) Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron, 80:97-112. (PubMed:24035762)
  10. Schaheen B et al. (2009) Derlin-dependent accumulation of integral membrane proteins at cell surfaces. J Cell Sci, 122:2228-39. (PubMed:19509052)
  11. Tambe Y et al. (2009) The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum. Cancer Lett, 283:74-83. (PubMed:19368996)
  12. Yuasa K et al. (2008) Trafficking of cGMP-dependent protein kinase II via interaction with Rab11. Biochem Biophys Res Commun, 374:522-6. (PubMed:18656450)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory