Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables voltage-gated chloride channel activity. Acts upstream of or within acinar cell differentiation; cell differentiation involved in salivary gland development; and retina development in camera-type eye. Predicted to be located in dendrite; perikaryon; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; gonad; hindlimb phalanx; notochord; and visual system. Used to study leukodystrophy and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2).