Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits identical protein binding activity. Involved in several processes, including actin filament polymerization; cellular response to interferon-gamma; and endosomal transport. Localizes to cell-cell junction; phagocytic vesicle; and vesicle membrane. Used to study IgA glomerulonephritis and Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Is expressed in brain; heart; liver; and spleen. Orthologous to human WAS (WASP actin nucleation promoting factor).