Automated description from the Alliance of Genome Resources
Exhibits glutamate-cysteine ligase activity and protein heterodimerization activity. Involved in several processes, including glutathione biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of cellular protein metabolic process. Localizes to the cytosol and glutamate-cysteine ligase complex. Used to study cataract. Human ortholog(s) of this gene implicated in cystic fibrosis; hemolytic anemia; and myocardial infarction. Is expressed in several structures, including alimentary system; metanephros; respiratory system; sensory organ; and telencephalon. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).