Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within heme biosynthetic process. Located in mitochondrial inner membrane. Is active in mitochondrial intermembrane space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase).