Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ppox. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 5, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ppox
  • participates in the following biological processes:
    • heme biosynthetic process ^[1]
    • oxidation-reduction process ^[1]
  • performs the following molecular functions:
    • oxygen-dependent protoporphyrinogen oxidase activity ^[1]
  • is located in the following cellular components:
    • intrinsic to mitochondrial inner membrane ^[1]
    • mitochondrion ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ppox:
  • participates in the following biological processes:
    • heme biosynthetic process
    • oxidation-reduction process
    • porphyrin-containing compound biosynthetic process
    • protoporphyrinogen IX metabolic process
  • performs the following molecular functions:
    • oxygen-dependent protoporphyrinogen oxidase activity
  • is located in the following cellular components:
    • integral to mitochondrial inner membrane
    • mitochondrial membrane
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Ppox encodes a protein or proteins that contain the following InterPro domains: Amine oxidase, NAD(P)-binding domain, Protoporphyrinogen oxidase, indicating that the gene product:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • nucleotide binding
    • oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ppox indicates that it:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane
    • mitochondrial inner membrane

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References

1. Ferreira GC et al. (1988) Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex. J Biol Chem, 263:3835-9. (PubMed:3346226)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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