Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; generation of neurons; and regulation of gene expression. Localizes to cytosol; nucleus; and transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor).