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Gene Ontology Classifications
hairy and enhancer of split 5 (Drosophila)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hes5. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Basak O et al. (2007) Identification of self-replicating multipotent progenitors in the embryonic nervous system by high Notch activity and Hes5 expression. Eur J Neurosci, 25:1006-22. (PubMed:17331197)
  2. Cau E et al. (2000) Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Development, 127:2323-32. (PubMed:10804175)
  3. Hatakeyama J et al. (2004) Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development, 131:5539-50. (PubMed:15496443)
  4. Hojo M et al. (2000) Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development, 127:2515-22. (PubMed:10821751)
  5. Imayoshi I et al. (2008) Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development, 135:2531-41. (PubMed:18579678)
  6. Jalali A et al. (2011) HeyL promotes neuronal differentiation of neural progenitor cells. J Neurosci Res, 89:299-309. (PubMed:21259317)
  7. Kamakura S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol, 6:547-54. (PubMed:15156153)
  8. Karlsson C et al. (2007) Notch and HES5 are regulated during human cartilage differentiation. Cell Tissue Res, 327:539-51. (PubMed:17093926)
  9. Kinameri E et al. (2008) Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS ONE, 3:e3859. (PubMed:19050759)
  10. Li W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A, 112:166-71. (PubMed:25535395)
  11. Liu A et al. (2006) A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. EMBO J, 25:4833-42. (PubMed:17006542)
  12. Ohtsuka T et al. (2001) Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. J Biol Chem, 276:30467-74. (PubMed:11399758)
  13. Ohtsuka T et al. (1999) Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J, 18:2196-207. (PubMed:10205173)
  14. Shimizu T et al. (2010) Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Development, 137:1875-85. (PubMed:20431123)
  15. Varnum-Finney B et al. (2008) Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus. Blood, 111:2615-20. (PubMed:18048645)
  16. Wall DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol, 184:101-12. (PubMed:19124651)
  17. Wu Y et al. (2003) Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. Dev Dyn, 226:675-89. (PubMed:12666205)
  18. Zine A et al. (2001) Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. J Neurosci, 21:4712-20. (PubMed:11425898)
  19. Zine A et al. (2002) Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice. Hear Res, 170:22-31. (PubMed:12208538)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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