Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aga. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Aga
  • participates in the following biological processes:
    • protein maturation ^[1]
  • performs the following molecular functions:
    • N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aga:
  • participates in the following biological processes:
    • protein deglycosylation
  • performs the following molecular functions:
    • N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
    • protein self-association
  • is located in the following cellular components:
    • endoplasmic reticulum
    • lysosome

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Summary text based on GO annotations supported by structural data

• Aga encodes a protein or proteins that contain the following InterPro domains: Peptidase T2, asparaginase 2, indicating that the gene product:
  • performs the following molecular functions:
    • hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aga indicates that it:
  • performs the following molecular functions:
    • hydrolase activity

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References

1. Tenhunen K et al. (1995) Molecular cloning, chromosomal assignment, and expression of the mouse aspartylglucosaminidase gene. Genomics, 30:244-50. (PubMed:8586423)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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