Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ppp1cb. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ppp1cb
  • participates in the following biological processes:
    • circadian regulation of gene expression ^[1]
    • protein dephosphorylation ^{[1, 2]}
    • regulation of circadian rhythm ^[1]
  • performs the following molecular functions:
    • phosphatase activity ^[1]
    • protein serine/threonine phosphatase activity ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[3]
• The gene product of Ppp1cb has been shown to bind to the gene products of Ppp1r3g. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ppp1cb
  • participates in the following biological processes:
    • entrainment of circadian clock by photoperiod ^[4]
    • regulation of circadian rhythm ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ppp1cb:
  • participates in the following biological processes:
    • protein dephosphorylation
    • regulation of cell adhesion
    • regulation of circadian rhythm
    • regulation of glycogen biosynthetic process
    • regulation of glycogen catabolic process
  • performs the following molecular functions:
    • myosin-light-chain-phosphatase activity
    • phosphoprotein phosphatase activity
    • protein kinase binding
  • is located in the following cellular components:
    • extracellular vesicular exosome
    • glycogen granule
    • MLL5-L complex
    • nucleus
    • protein phosphatase type 1 complex
    • PTW/PP1 phosphatase complex

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Summary text based on GO annotations supported by structural data

• Ppp1cb encodes a protein or proteins that contain the following InterPro domains: Metallophosphoesterase domain, Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase, indicating that the gene product:
  • performs the following molecular functions:
    • hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ppp1cb indicates that it:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • cell cycle
    • cell division
    • glycogen metabolic process
    • rhythmic process
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding

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References

1. Lee HM et al. (2011) The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A, 108:16451-6. (PubMed:21930935)
2. Llorian M et al. (2004) SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Biochem J, 378:229-38. (PubMed:14640981)
3. Luo X et al. (2011) Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis. Diabetes, 60:1435-45. (PubMed:21471512)
4. Schmutz I et al. (2011) Protein Phosphatase 1 (PP1) Is a Post-Translational Regulator of the Mammalian Circadian Clock. PLoS One, 6:e21325. (PubMed:21712997)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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