Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atp6v0a2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Atp6v0a2
  • is located in the following cellular components:
    • acrosomal vesicle ^[2]
• The gene product of Atp6v0a2 has been shown to bind to the gene products of Cyth2. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Atp6v0a2:
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Atp6v0a2 encodes a protein or proteins that contain the following InterPro domains: ATPase, V0/A0 complex subunit a, V-type proton ATPase subunit a, indicating that the gene product:
  • participates in the following biological processes:
    • ATP hydrolysis coupled proton transport
  • performs the following molecular functions:
    • hydrogen ion transmembrane transporter activity
  • is located in the following cellular components:
    • proton-transporting V-type ATPase, V0 domain
    • vacuolar proton-transporting V-type ATPase, V0 domain

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Atp6v0a2 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • proton transport
    • transport
  • is located in the following cellular components:
    • endosome
    • integral to membrane
    • membrane

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References

1. Hurtado-Lorenzo A et al. (2006) V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol, 8:124-36. (PubMed:16415858)
2. Sun-Wada GH et al. (2002) A proton pump ATPase with testis-specific E1-subunit isoform required for acrosome acidification. J Biol Chem, 277:18098-105. (PubMed:11872743)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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