Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protease binding activity; receptor ligand activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; macrophage activation; and positive regulation of cell communication. Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of intracellular signal transduction; and regulation of gene expression. Located in several cellular components, including external side of plasma membrane; phagocytic cup; and recycling endosome. Is active in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; integumental system; and lung. Used to study aortic valve stenosis; heart valve disease; inflammatory bowel disease; rheumatoid arthritis; and spondyloarthropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).