Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lta. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lta
  • participates in the following biological processes:
    • humoral immune response ^[1]
    • lymph node development ^{[1, 2, 4, 5, 6]}
• Researchers have inferred, based on genetic interactions, that the gene product of Lta
  • participates in the following biological processes:
    • defense response to Gram-positive bacterium based on interactions with Tnf ^[3]
    • negative regulation of growth of symbiont in host based on interactions with Tnf ^[3]
    • positive regulation of chronic inflammatory response to antigenic stimulus based on interactions with Tnf ^[3]
    • positive regulation of humoral immune response mediated by circulating immunoglobulin based on interactions with Tnf ^[3]
    • positive regulation of interferon-gamma production based on interactions with Tnf ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lta:
  • participates in the following biological processes:
    • negative regulation of fibroblast proliferation
    • positive regulation of apoptotic process

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Summary text based on GO annotations supported by structural data

• Lta encodes a protein or proteins that contain the following InterPro domains: Tumour necrosis factor, Tumour necrosis factor alpha/beta/c, Tumour necrosis factor beta/lymphotoxin alpha, Tumour necrosis factor, conserved site, Tumour necrosis factor-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lta indicates that it:
  • performs the following molecular functions:
    • cytokine activity
  • is located in the following cellular components:
    • extracellular region
    • extracellular space
    • membrane

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References

1. Banks TA et al. (1995) Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol, 155:1685-93. (PubMed:7636227)
2. De Togni P et al. (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin [see comments] Science, 264:703-7. (PubMed:8171322)
3. Hultgren O et al. (1998) TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol, 161:5937-42. (PubMed:9834074)
4. Korner H et al. (1997) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol, 27:2600-9. (PubMed:9368616)
5. Matsumoto M et al. (1999) Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J Immunol, 163:1584-91. (PubMed:10415063)
6. Sean Riminton D et al. (1998) Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med, 187:1517-28. (PubMed:9565643)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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