Automated description from the Alliance of Genome Resources
Exhibits DNA-dependent protein kinase activity; double-stranded DNA binding activity; and enzyme binding activity. Involved in several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and immune system development. Localizes to the nucleus. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in several structures, including central nervous system; neural retina; and thymus primordium. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit).