Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in several processes, including negative regulation of ferroptosis; response to oxidative stress; and spermatogenesis. Localizes to cytosol; mitochondrion; and nuclear envelope. Is expressed in several structures, including alimentary system; embryo ectoderm; extraembryonic component; nervous system; and sensory organ. Orthologous to human GPX4 (glutathione peroxidase 4).