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Gene Ontology Classifications
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nfkbia. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
  1. Basak S et al. (2007) A fourth IkappaB protein within the NF-kappaB signaling module. Cell, 128:369-81. (PubMed:17254973)
  2. Bhatia N et al. (2002) Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. Oncogene, 21:1501-9. (PubMed:11896578)
  3. Chang M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol, 12:1002-9. (PubMed:21874024)
  4. Chang NS. (2002) The Non-ankyrin C Terminus of Ikappa Balpha Physically Interacts with p53 in Vivo and Dissociates in Response to Apoptotic Stress, Hypoxia, DNA Damage, and Transforming Growth Factor-beta 1-mediated Growth Suppression. J Biol Chem, 277:10323-31. (PubMed:11799106)
  5. Gao Z et al. (2006) Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function. J Biol Chem, 281:4540-7. (PubMed:16371367)
  6. Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature, 424:743-8. (PubMed:12872135)
  7. Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity, 28:246-57. (PubMed:18261938)
  8. Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science, 307:731-4. (PubMed:15692051)
  9. Li H et al. (2012) Regulation of NF-kappaB activity by competition between RelA acetylation and ubiquitination. Oncogene, 31:611-23. (PubMed:21706061)
  10. Mathes E et al. (2008) NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J, 27:1357-67. (PubMed:18401342)
  11. Mitola S et al. (2008) Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm. Blood, 112:1154-7. (PubMed:18505784)
  12. Mohamed JS et al. (2010) Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J, 24:3330-40. (PubMed:20442316)
  13. Mulero MC et al. (2013) Chromatin-bound IkappaBalpha regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell, 24:151-66. (PubMed:23850221)
  14. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
  15. Rupec RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity, 22:479-91. (PubMed:15845452)
  16. Shih VF et al. (2012) Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-kappaB pathways. Nat Immunol, 13:1162-70. (PubMed:23086447)
  17. Tashiro K et al. (1997) Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha. Proc Natl Acad Sci U S A, 94:7862-7. (PubMed:9223278)
  18. Turchinovich G et al. (2011) Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-gamma-Secreting versus Interleukin-17-Secreting gammadelta T Cells. Immunity, 35:59-68. (PubMed:21737317)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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