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Gene Ontology Classifications
peroxisome proliferator activated receptor alpha

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ppara. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. . () , :. (PubMed:)
  2. Aoyama T et al. (1998) Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha J Biol Chem, 273:5678-84. (PubMed:9488698)
  3. Cheng P et al. (2011) Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha. FEBS Lett, 585:3403-8. (PubMed:22001208)
  4. Evsikov AV et al. (2004) Systems biology of the 2-cell mouse embryo. Cytogenet Genome Res, 105:240-50. (PubMed:15237213)
  5. Finck BN et al. (2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab, 4:199-210. (PubMed:16950137)
  6. Fu J et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature, 425:90-3. (PubMed:12955147)
  7. Goetzman ES et al. (2005) Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice. Mol Genet Metab, 84:39-47. (PubMed:15639194)
  8. Helledie T et al. (2002) The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. J Biol Chem, 277:26821-30. (PubMed:12015306)
  9. Jeffery B et al. (2004) Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. Arch Biochem Biophys, 429:231-6. (PubMed:15313227)
  10. Kim HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol, 30:3126-39. (PubMed:20385772)
  11. Michalik L et al. (2001) Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol, 154:799-814. (PubMed:11514592)
  12. Napal L et al. (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J Mol Biol, 354:751-9. (PubMed:16271724)
  13. Patsouris D et al. (2004) PPARalpha governs glycerol metabolism. J Clin Invest, 114:94-103. (PubMed:15232616)
  14. Schmuth M et al. (2002) Role of Peroxisome Proliferator-Activated Receptor alpha in Epidermal Development in Utero. J Invest Dermatol, 119:1298-303. (PubMed:12485431)
  15. Schmutz I et al. (2010) The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev, 24:345-57. (PubMed:20159955)
  16. Seale P et al. (2008) PRDM16 controls a brown fat/skeletal muscle switch. Nature, 454:961-7. (PubMed:18719582)
  17. Sehic A et al. (2009) Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse. Eur J Oral Sci, 117:93-104. (PubMed:19320717)
  18. Westin MA et al. (2004) Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. J Biol Chem, 279:21841-8. (PubMed:15007068)
  19. Yamaguchi T et al. (2006) MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. J Biol Chem, 281:14232-40. (PubMed:16571721)
  20. Yamauchi T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423:762-9. (PubMed:12802337)
  21. Zhu Y et al. (1997) Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem, 272:25500-6. (PubMed:9325263)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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