Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable 11-beta-hydroxysteroid dehydrogenase (NAD+) activity; NAD binding activity; and steroid binding activity. Acts upstream of or within female pregnancy. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including brain; ear; genitourinary system; hemolymphoid system; and trophectoderm. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2).