Automated description from the Alliance of Genome Resources
Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in collagen-activated tyrosine kinase receptor signaling pathway; glomerular basement membrane development; and negative regulation of angiogenesis. Localizes to the collagen type IV trimer. Used to study autosomal recessive Alport syndrome. Human ortholog(s) of this gene implicated in Alport syndrome; autosomal dominant Alport syndrome; autosomal recessive Alport syndrome; and end stage renal failure. Orthologous to human COL4A3 (collagen type IV alpha 3 chain).