Automated description from the Alliance of Genome Resources (Release 3.1.1)
Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in collagen-activated tyrosine kinase receptor signaling pathway; glomerular basement membrane development; and negative regulation of angiogenesis. Localizes to collagen type IV trimer. Is expressed in blood vessel; brain; and genitourinary system. Used to study autosomal recessive Alport syndrome. Human ortholog(s) of this gene implicated in Alport syndrome; autosomal dominant Alport syndrome; autosomal recessive Alport syndrome; benign familial hematuria; and end stage renal disease. Orthologous to human COL4A3 (collagen type IV alpha 3 chain).