Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coregulator activity. Involved in several processes, including cranial nerve development; embryonic morphogenesis; and regulation of gene expression. Acts upstream of or within several processes, including camera-type eye development; face morphogenesis; and nervous system development. Located in clathrin-coated pit and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; jaw; and sensory organ. Used to study orofacial cleft. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha).