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Gene Ontology Classifications

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GO curators for mouse genes have assigned the following annotations to the gene product of Lep. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Anand A et al. (2000) In vivo modulation of Hmgic reduces obesity. Nat Genet, 24:377-80. (PubMed:10742101)
  2. Buyse M et al. (2001) Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes. FASEB J, 15:1357-66. (PubMed:11387233)
  3. Galloway CA et al. (2010) Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes. Biochim Biophys Acta, 1802:976-85. (PubMed:20541607)
  4. Gruen ML et al. (2005) Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res, 46:2007-14. (PubMed:15995171)
  5. Hahm S et al. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci, 22:6929-38. (PubMed:12177191)
  6. Hyogo H et al. (2002) Leptin Promotes Biliary Cholesterol Elimination during Weight Loss in ob/ob Mice by Regulating the Enterohepatic Circulation of Bile Salts. J Biol Chem, 277:34117-24. (PubMed:12114517)
  7. Ishii M et al. (2003) Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A, 100:10540-5. (PubMed:12925742)
  8. Jiao Y et al. (2012) Mex3c mutation reduces adiposity and increases energy expenditure. Mol Cell Biol, 32:4350-62. (PubMed:22927639)
  9. Kristensen P et al. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature, 393:72-6. (PubMed:9590691)
  10. Lee JH et al. (2012) Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab, 16:311-21. (PubMed:22958918)
  11. Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell, 130:456-69. (PubMed:17693256)
  12. Li N et al. (1999) NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice. Brain Res, 849:34-44. (PubMed:10592285)
  13. Luque RM et al. (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology, 147:2754-63. (PubMed:16513828)
  14. Maeda K et al. (2003) Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes, 52:300-7. (PubMed:12540600)
  15. Marroqui L et al. (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia, null:null. (PubMed:21234744)
  16. Mikhail AA et al. (1997) Leptin stimulates fetal and adult erythroid and myeloid development. Blood, 89:1507-12. (PubMed:9057630)
  17. Miyazaki M et al. (2003) Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem, 278:33904-11. (PubMed:12815040)
  18. Peterson JM et al. (2010) C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem, 285:39691-701. (PubMed:20952387)
  19. Szczypka MS et al. (2000) Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet, 25:102-4. (PubMed:10802666)
  20. Tartaglia LA. (1997) The leptin receptor. J Biol Chem, 272:6093-6. (PubMed:9102398)
  21. Watson E et al. (2005) VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology, 146:5151-63. (PubMed:16141392)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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