Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits SMAD binding activity. Involved in several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cytosol; extrinsic component of endoplasmic reticulum membrane; and nuclear lumen. Colocalizes with heterochromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human PML (promyelocytic leukemia).