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Gene Ontology Classifications
RAR-related orphan receptor alpha

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rora. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bakalian A et al. (1992) Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol, 143:129-39. (PubMed:1565842)
  2. Chopra AR et al. (2008) Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science, 322:1395-9. (PubMed:19039140)
  3. Forman BM et al. (1994) Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol, 8:1253-61. (PubMed:7838158)
  4. Gold DA et al. (2003) RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron, 40:1119-31. (PubMed:14687547)
  5. Ikeda M et al. (1994) Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami. Neurosci Lett, 168:65-8. (PubMed:7518067)
  6. Journiac N et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc Natl Acad Sci U S A, 106:21365-70. (PubMed:19955433)
  7. Kang HS et al. (2007) Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics, 31:281-94. (PubMed:17666523)
  8. Lau P et al. (2004) RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem, 279:36828-40. (PubMed:15199055)
  9. Liu C et al. (2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature, 447:477-81. (PubMed:17476214)
  10. Nakagawa S et al. (1996) Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse. Eur J Neurosci, 8:2644-51. (PubMed:8996814)
  11. Ohoka N et al. (2009) The orphan nuclear receptor ROR{alpha} restrains adipocyte differentiation through a reduction of C/EBP{beta} activity and perilipin gene expression. Mol Endocrinol, 23:759-71. (PubMed:19324970)
  12. Poliandri AH et al. (2011) Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). J Biol Rhythms, 26:187-99. (PubMed:21628546)
  13. Raspe E et al. (2001) Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha. J Biol Chem, 276:2865-71. (PubMed:11053433)
  14. Retnakaran R et al. (1994) Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol, 8:1234-44. (PubMed:7838156)
  15. Saito T et al. (2013) Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation, 127:104-14. (PubMed:23172836)
  16. Serra HG et al. (2006) RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice. Cell, 127:697-708. (PubMed:17110330)
  17. Takeda Y et al. (2013) Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation. Nucleic Acids Res, 41:6992-7008. (PubMed:23723244)
  18. Takeda Y et al. (2012) RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Res, 40:8519-35. (PubMed:22753030)
  19. Wada T et al. (2008) Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol, 73:891-9. (PubMed:18055760)
  20. Wang X et al. (2010) Interaction of MAGED1 with nuclear receptors affects circadian clock function. EMBO J, 29:1389-400. (PubMed:20300063)
  21. Wang Y et al. (2010) Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem, 285:5013-25. (PubMed:19965867)
  22. Yang XO et al. (2008) T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity, 28:29-39. (PubMed:18164222)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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