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Gene Ontology Classifications
atonal homolog 1 (Drosophila)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Atoh1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bermingham NA et al. (1999) Math1: an essential gene for the generation of inner ear hair cells. Science, 284:1837-41. (PubMed:10364557)
  2. Chen P et al. (2002) The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development, 129:2495-505. (PubMed:11973280)
  3. Doetzlhofer A et al. (2009) Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell, 16:58-69. (PubMed:19154718)
  4. Farah MH et al. (2000) Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development, 127:693-702. (PubMed:10648228)
  5. Gazit R et al. (2004) Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. Development, 131:903-13. (PubMed:14757642)
  6. Jensen P et al. (2002) Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse. J Neurosci, 22:8110-6. (PubMed:12223565)
  7. Jensen P et al. (2004) Analysis of cerebellar development in math1 null embryos and chimeras. J Neurosci, 24:2202-11. (PubMed:14999071)
  8. Jones JM et al. (2006) Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J Neurosci, 26:550-8. (PubMed:16407553)
  9. Krizhanovsky V et al. (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech Dev, 123:67-75. (PubMed:16325379)
  10. Krizhanovsky V et al. (2006) Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites. J Mol Neurosci, 28:211-29. (PubMed:16679559)
  11. Li W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A, 112:166-71. (PubMed:25535395)
  12. Matei V et al. (2005) Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev Dyn, 234:633-50. (PubMed:16145671)
  13. Pan N et al. (2010) Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res, null:null. (PubMed:21146598)
  14. Saba R et al. (2005) Commissural neuron identity is specified by a homeodomain protein, Mbh1, that is directly downstream of Math1. Development, 132:2147-55. (PubMed:15788459)
  15. Scheffer D et al. (2007) Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. FEBS Lett, 581:4651-6. (PubMed:17826772)
  16. Wang VY et al. (2005) Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron, 48:31-43. (PubMed:16202707)
  17. Woods C et al. (2004) Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nat Neurosci, 7:1310-8. (PubMed:15543141)
  18. Zheng JL et al. (2000) Hes1 is a negative regulator of inner ear hair cell differentiation Development, 127:4551-60. (PubMed:11023859)
  19. Zine A et al. (2002) Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice. Hear Res, 170:22-31. (PubMed:12208538)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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