Automated description from the Alliance of Genome Resources (Release 4.0)
Enables microtubule binding activity and protein homodimerization activity. Involved in cytoskeleton organization and retrograde axonal transport. Acts upstream of or within axonogenesis; cytoplasmic microtubule organization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including H zone; cytoskeleton; and endoplasmic reticulum. Is active in Z disc and type III intermediate filament. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina nuclear layer. Used to study hereditary sensory and autonomic neuropathy type 6 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 6. Orthologous to human DST (dystonin).