Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including cellular response to radiation; negative regulation of cell cycle; and signal transduction by p53 class mediator. Localizes to cyclin-dependent protein kinase holoenzyme complex; cytosol; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hepatocellular carcinoma and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in malignant glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).