Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; osteoclast differentiation; and regulation of osteoclast differentiation. Localizes to the nucleus. Used to study Tietz syndrome; Waardenburg's syndrome (multiple); ocular albinism with sensorineural deafness; and osteosclerosis (multiple). Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and ocular albinism with sensorineural deafness. Is expressed in several structures, including alimentary system; central nervous system; integumental system; mesenchyme derived from neural crest; and sensory organ. Orthologous to human MITF (melanocyte inducing transcription factor).