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Gene Ontology Classifications
Symbol
Name
ID
Mitf
microphthalmia-associated transcription factor
MGI:104554

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mitf. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Carreira S et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature, 433:764-9. (PubMed:15716956)
  2. Horsford DJ et al. (2005) Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development, 132:177-87. (PubMed:15576400)
  3. Lang D et al. (2005) Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature, 433:884-7. (PubMed:15729346)
  4. Maruyama K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med, 210:1947-60. (PubMed:23980096)
  5. Matsumoto M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J Biol Chem, 279:45969-79. (PubMed:15304486)
  6. McGill GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell, 109:707-18. (PubMed:12086670)
  7. Moore KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics, 125:421-30. (PubMed:2379821)
  8. Murakami M et al. (2003) Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor. Biochem Biophys Res Commun, 311:4-10. (PubMed:14575687)
  9. Opdecamp K et al. (1997) Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development, 124:2377-86. (PubMed:9199364)
  10. Steingrimsson E et al. (2002) Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A, 99:4477-82. (PubMed:11930005)
  11. Widlund HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol, 158:1079-87. (PubMed:12235125)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory