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Gene Ontology Classifications
tumor necrosis factor (ligand) superfamily, member 4

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GO curators for mouse genes have assigned the following annotations to the gene product of Tnfsf4. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Arestides RS et al. (2002) Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. Eur J Immunol, 32:2874-80. (PubMed:12355440)
  2. Blazquez AB et al. (2008) Gastrointestinal dendritic cells promote Th2 skewing via OX40L. J Immunol, 180:4441-50. (PubMed:18354165)
  3. Ekkens MJ et al. (2003) The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. J Immunol, 170:384-93. (PubMed:12496423)
  4. Flynn S et al. (1998) CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J Exp Med, 188:297-304. (PubMed:9670042)
  5. Hodgkins SR et al. (2010) NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization. Respir Res, 11:102. (PubMed:20659336)
  6. Jenkins SJ et al. (2007) Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J Immunol, 179:3515-23. (PubMed:17785785)
  7. Karulf M et al. (2010) OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis. J Immunol, 185:4856-62. (PubMed:20844189)
  8. Kurche JS et al. (2010) Comparison of OX40 Ligand and CD70 in the Promotion of CD4+ T Cell Responses. J Immunol, 185:2106-15. (PubMed:20639485)
  9. Obermeier F et al. (2003) OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice. Eur J Immunol, 33:3265-74. (PubMed:14635034)
  10. Paigen B et al. (1987) Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci U S A, 84:3763-7. (PubMed:3473481)
  11. Rogers PR et al. (2001) OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity, 15:445-55. (PubMed:11567634)
  12. Soroosh P et al. (2006) OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity. J Immunol, 176:5975-87. (PubMed:16670306)
  13. Stuber E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity, 2:507-21. (PubMed:7749983)
  14. Xiao X et al. (2008) OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. J Immunol, 181:3193-201. (PubMed:18713990)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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