Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ccl11. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ccl11
  • participates in the following biological processes:
    • branching involved in mammary gland duct morphogenesis ^[1]
    • mammary duct terminal end bud growth ^[1]
    • positive regulation of angiogenesis ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ccl11:
  • participates in the following biological processes:
    • actin filament organization
    • cytoskeleton organization
    • eosinophil chemotaxis
    • ERK1 and ERK2 cascade
    • mast cell chemotaxis
    • positive regulation of actin filament polymerization
    • positive regulation of cell migration
    • positive regulation of endothelial cell proliferation
    • positive regulation of Rac GTPase activity
    • regulation of cell shape
  • performs the following molecular functions:
    • chemokine activity
  • is located in the following cellular components:
    • extracellular region
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Ccl11 encodes a protein or proteins that contain the following InterPro domains: CC chemokine, conserved site, Chemokine interleukin-8-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • immune response

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ccl11 indicates that it:
  • participates in the following biological processes:
    • chemotaxis
    • inflammatory response
  • performs the following molecular functions:
    • cytokine activity

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References

1. Gouon-Evans V et al. (2000) Postnatal mammary gland development requires macrophages and eosinophils. Development, 127:2269-82. (PubMed:10804170)
2. Takeda A et al. (2009) CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature, 460:225-30. (PubMed:19525930)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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