Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cxcl12. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cxcl12
  • participates in the following biological processes:
    • brain development ^[4]
    • cell chemotaxis ^[4]
    • germ cell development ^[7]
    • germ cell migration ^[7]
    • induction of positive chemotaxis ^[7]
    • positive regulation of cell migration ^[7]
    • regulation of cell migration ^[4]
  • performs the following molecular functions:
    • chemokine activity ^[4]
  • is located in the following cellular components:
    • external side of plasma membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cxcl12
  • participates in the following biological processes:
    • ameboidal cell migration ^[2]
    • motor neuron axon guidance ^[6]
    • patterning of blood vessels ^[2]
    • T cell proliferation ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Cxcl12
  • participates in the following biological processes:
    • regulation of cell migration based on interactions with Tff2 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cxcl12:
  • participates in the following biological processes:
    • adult locomotory behavior
    • chemokine-mediated signaling pathway
    • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
    • negative regulation of leukocyte apoptotic process
    • neuron migration
    • organ regeneration
    • positive regulation of axon extension involved in axon guidance
    • positive regulation of cell adhesion
    • positive regulation of cell migration
    • positive regulation of cell proliferation
    • positive regulation of dopamine secretion
    • positive regulation of endothelial cell proliferation
    • positive regulation of monocyte chemotaxis
    • positive regulation of neuron differentiation
    • positive regulation of T cell migration
    • regulation of calcium ion transport
    • telencephalon cell migration
  • performs the following molecular functions:
    • chemokine receptor binding
    • CXCR chemokine receptor binding
  • is located in the following cellular components:
    • extracellular space
    • extracellular vesicular exosome
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Cxcl12 encodes a protein or proteins that contain the following InterPro domains: Chemokine interleukin-8-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • immune response
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cxcl12 indicates that it:
  • participates in the following biological processes:
    • chemotaxis
  • performs the following molecular functions:
    • cytokine activity
    • growth factor activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol, 173:1682-92. (PubMed:19008373)
2. Ara T et al. (2005) The role of CXCL12 in the organ-specific process of artery formation. Blood, 105:3155-61. (PubMed:15626744)
3. Ara T et al. (2003) A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol, 170:4649-55. (PubMed:12707343)
4. Bagri A et al. (2002) The chemokine SDF1 regulates migration of dentate granule cells. Development, 129:4249-60. (PubMed:12183377)
5. Dubeykovskaya Z et al. (2009) Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J Biol Chem, 284:3650-62. (PubMed:19064997)
6. Lieberam I et al. (2005) A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron, 47:667-79. (PubMed:16129397)
7. Molyneaux KA et al. (2003) The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development, 130:4279-86. (PubMed:12900445)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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