Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and ankyrin repeat binding activity. Involved in several processes, including animal organ development; negative regulation of protein metabolic process; and regulation of macromolecule biosynthetic process. Localizes to the cytosol; glutamatergic synapse; and nuclear chromatin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Is expressed in several structures, including alimentary system; genitourinary system; musculature; respiratory system; and skin. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit).