Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables proton transmembrane transporter activity. Involved in regulation of pH and synaptic vesicle lumen acidification. Acts upstream of or within several processes, including inorganic ion homeostasis; renal sodium ion transport; and renal water homeostasis. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and microvillus. Is expressed in several structures, including alimentary system; limb; metanephros; nervous system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness and enlarged vestibular aqueduct. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V1B1 (ATPase H+ transporting V1 subunit B1).