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Gene Ontology Classifications
vascular endothelial growth factor A

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vegfa. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. The expression of some isoforms derived from AUG start codon is affected by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Amura CR et al. (2007) VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. Am J Physiol Cell Physiol, 293:C419-28. (PubMed:17475663)
  2. Breier G et al. (1992) Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development, 114:521-32. (PubMed:1592003)
  3. Cariboni A et al. (2011) VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development, 138:3723-33. (PubMed:21828096)
  4. Carmeliet P et al. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [see comments] Nat Med, 5:495-502. (PubMed:10229225)
  5. Chislock EM et al. (2013) Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS One, 8:e85231. (PubMed:24367707)
  6. Christofori G et al. (1995) Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol, 9:1760-70. (PubMed:8614412)
  7. Compernolle V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med, 8:702-10. (PubMed:12053176)
  8. Del Moral PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol, 290:177-88. (PubMed:16375885)
  9. Duan LJ et al. (2003) Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice. Biol Reprod, 69:1852-8. (PubMed:12890722)
  10. Erskine L et al. (2011) VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron, 70:951-65. (PubMed:21658587)
  11. Fantin A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development, 141:556-62. (PubMed:24401374)
  12. Gao X et al. (2005) Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development, 132:5437-49. (PubMed:16291795)
  13. Halder JB et al. (2000) Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis, 26:213-24. (PubMed:10705382)
  14. Healy AM et al. (2000) VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung Dev Dyn, 219:341-52. (PubMed:11066091)
  15. Heishi T et al. (2010) Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am J Pathol, 176:1950-8. (PubMed:20133819)
  16. Hiratsuka S et al. (2005) Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol Cell Biol, 25:355-63. (PubMed:15601856)
  17. Krilleke D et al. (2007) Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. J Biol Chem, 282:28045-56. (PubMed:17626017)
  18. Kulkarni RM et al. (2009) NFATc1 regulates lymphatic endothelial development. Mech Dev, 126:350-65. (PubMed:19233265)
  19. Lavine KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev, 20:1651-66. (PubMed:16778080)
  20. Maes C et al. (2004) Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest, 113:188-99. (PubMed:14722611)
  21. Marchio S et al. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell, 5:151-62. (PubMed:14998491)
  22. Marneros AG et al. (2005) Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol, 167:1451-9. (PubMed:16251428)
  23. Martin R et al. (2004) SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development, 131:693-702. (PubMed:14729577)
  24. Milosevic J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J Neurosci, 27:412-21. (PubMed:17215402)
  25. Muller SM et al. (2005) Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc Natl Acad Sci U S A, 102:10587-92. (PubMed:16027358)
  26. Ng YS et al. (2001) Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn, 220:112-21. (PubMed:11169844)
  27. Novitskiy SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood, 112:1822-31. (PubMed:18559975)
  28. Purpura KA et al. (2008) Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner. Stem Cells, 26:2832-42. (PubMed:18772315)
  29. Roberts AE et al. (2007) Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary. Biol Reprod, 76:218-23. (PubMed:17050862)
  30. Rolny C et al. (2005) Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Exp Cell Res, 308:381-93. (PubMed:15919073)
  31. Rossiter H et al. (2007) Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function. FASEB J, 21:3994-4004. (PubMed:17625068)
  32. Shan B et al. (2012) RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr Relat Cancer, 19:13-27. (PubMed:22009797)
  33. Sugihara T et al. (1998) A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115. J Biol Chem, 273:3033-8. (PubMed:9446618)
  34. Thurston G et al. (1999) Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science, 286:2511-4. (PubMed:10617467)
  35. van den Akker NM et al. (2008) Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovasc Res, 78:366-75. (PubMed:18093989)
  36. Vieira JM et al. (2007) Selective requirements for NRP1 ligands during neurovascular patterning. Development, 134:1833-43. (PubMed:17428830)
  37. Wu JA et al. (2008) Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol Reprod, 79:1054-61. (PubMed:18753609)
  38. Zelzer E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development, 131:2161-71. (PubMed:15073147)
  39. Zhao L et al. (2005) Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech Dev, 122:877-86. (PubMed:15927453)
  40. Zheng H et al. (2003) The transcription factor Net regulates the angiogenic switch. Genes Dev, 17:2283-97. (PubMed:12975317)
  41. Zimmerman MW et al. (2014) Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. J Biol Chem, 289:5904-13. (PubMed:24403062)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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