Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vegfa. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Vegfa
  • participates in the following biological processes:
    • angiogenesis ^{[12, 21, 27]}
    • blood vessel morphogenesis ^[19]
    • branching morphogenesis of a tube ^[5]
    • cell migration ^[9]
    • lung development ^[5]
    • positive regulation of angiogenesis ^[8]
    • positive regulation of branching involved in ureteric bud morphogenesis ^[7]
    • positive regulation of cell proliferation ^[1]
    • positive regulation of endothelial cell proliferation ^[2]
    • positive regulation of lymphangiogenesis ^[8]
    • positive regulation of mesenchymal cell proliferation ^[5]
    • positive regulation of vascular permeability ^[21]
    • vascular endothelial growth factor receptor signaling pathway ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[27]
    • extracellular space ^{[1, 2, 4, 17, 24]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Vegfa
  • participates in the following biological processes:
    • angiogenesis ^{[6, 11, 20, 25]}
    • artery morphogenesis ^[3]
    • behavior ^[3]
    • blood vessel development ^{[13, 26]}
    • blood vessel morphogenesis ^[16]
    • camera-type eye morphogenesis ^[13]
    • cardiac muscle fiber development ^[3]
    • cardiac vascular smooth muscle cell development ^[22]
    • cell maturation ^[4]
    • cell proliferation ^[11]
    • coronary artery morphogenesis ^[22]
    • coronary vein morphogenesis ^[22]
    • epithelial cell differentiation ^[13]
    • eye photoreceptor cell development ^[13]
    • growth ^[3]
    • heart morphogenesis ^[3]
    • in utero embryonic development ^[3]
    • kidney development ^[3]
    • lactation ^[20]
    • lung development ^{[4, 26]}
    • lymph vessel morphogenesis ^[22]
    • mammary gland alveolus development ^[20]
    • mesoderm development ^[6]
    • negative regulation of apoptotic process ^[25]
    • outflow tract morphogenesis ^[22]
    • ovarian follicle development ^[18]
    • patterning of blood vessels ^[23]
    • positive regulation of epithelial cell proliferation ^[26]
    • post-embryonic camera-type eye development ^[3]
    • primitive erythrocyte differentiation ^[14]
    • surfactant homeostasis ^[4]
    • vasculature development ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Vegfa
  • participates in the following biological processes:
    • angiogenesis based on interactions with Angpt2 ^[10]
    • blood vessel morphogenesis based on interactions with Shb ^[19]
    • cell migration based on interactions with Flt1, Kdr ^[9]
    • dopaminergic neuron differentiation based on interactions with Hif1a ^[15]
    • positive regulation of neuroblast proliferation based on interactions with Hif1a ^[15]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Vegfa:
  • participates in the following biological processes:
    • activation of protein kinase activity
    • angiogenesis
    • basophil chemotaxis
    • blood vessel remodeling
    • cell migration involved in sprouting angiogenesis
    • cellular response to hypoxia
    • cellular response to vascular endothelial growth factor stimulus
    • endothelial cell chemotaxis
    • induction of positive chemotaxis
    • lung alveolus development
    • macrophage differentiation
    • monocyte differentiation
    • mRNA stabilization
    • negative regulation of apoptotic process
    • negative regulation of bone resorption
    • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    • negative regulation of transcription from RNA polymerase II promoter
    • nervous system development
    • positive chemotaxis
    • positive regulation of angiogenesis
    • positive regulation of blood vessel endothelial cell migration
    • positive regulation of cell adhesion
    • positive regulation of cell migration
    • positive regulation of cell migration involved in sprouting angiogenesis
    • positive regulation of cell proliferation
    • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
    • positive regulation of cellular component movement
    • positive regulation of CREB transcription factor activity
    • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
    • positive regulation of endothelial cell migration
    • positive regulation of endothelial cell proliferation
    • positive regulation of focal adhesion assembly
    • positive regulation of gene expression
    • positive regulation of intracellular protein kinase cascade
    • positive regulation of MAP kinase activity
    • positive regulation of mast cell chemotaxis
    • positive regulation of p38MAPK cascade
    • positive regulation of peptidyl-serine phosphorylation
    • positive regulation of peptidyl-tyrosine autophosphorylation
    • positive regulation of peptidyl-tyrosine phosphorylation
    • positive regulation of positive chemotaxis
    • positive regulation of protein autophosphorylation
    • positive regulation of protein complex assembly
    • positive regulation of protein kinase C signaling cascade
    • positive regulation of protein phosphorylation
    • positive regulation of receptor activity
    • positive regulation of receptor internalization
    • positive regulation of signal transduction
    • positive regulation of smooth muscle cell proliferation
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
    • positive regulation of vascular endothelial growth factor receptor signaling pathway
    • positive regulation of vascular permeability
    • regulation of cell shape
    • regulation of transcription from RNA polymerase II promoter
    • response to hypoxia
    • T-helper 1 type immune response
    • vascular endothelial growth factor receptor signaling pathway
  • performs the following molecular functions:
    • cell surface binding
    • chemoattractant activity
    • cytokine activity
    • fibronectin binding
    • growth factor activity
    • heparin binding
    • identical protein binding
    • platelet-derived growth factor receptor binding
    • protein heterodimerization activity
    • protein homodimerization activity
    • receptor agonist activity
    • vascular endothelial growth factor receptor 1 binding
    • vascular endothelial growth factor receptor 2 binding
    • vascular endothelial growth factor receptor binding
  • is located in the following cellular components:
    • basement membrane
    • cell surface
    • cytoplasm
    • extracellular space
    • membrane-bounded vesicle
    • secretory granule

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Summary text based on GO annotations supported by structural data

• Vegfa encodes a protein or proteins that contain the following InterPro domains: Platelet-derived growth factor (PDGF), Platelet-derived growth factor, conserved site, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Vegfa indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • positive regulation of cell division
  • is located in the following cellular components:
    • extracellular region
    • membrane
    • plasma membrane

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References

1. Amura CR et al. (2007) VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice. Am J Physiol Cell Physiol, 293:C419-28. (PubMed:17475663)
2. Breier G et al. (1992) Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development, 114:521-32. (PubMed:1592003)
3. Carmeliet P et al. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [see comments] Nat Med, 5:495-502. (PubMed:10229225)
4. Compernolle V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med, 8:702-10. (PubMed:12053176)
5. Del Moral PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol, 290:177-88. (PubMed:16375885)
6. Duan LJ et al. (2003) Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice. Biol Reprod, 69:1852-8. (PubMed:12890722)
7. Gao X et al. (2005) Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development, 132:5437-49. (PubMed:16291795)
8. Heishi T et al. (2010) Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am J Pathol, 176:1950-8. (PubMed:20133819)
9. Hiratsuka S et al. (2005) Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol Cell Biol, 25:355-63. (PubMed:15601856)
10. Lavine KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev, 20:1651-66. (PubMed:16778080)
11. Maes C et al. (2004) Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest, 113:188-99. (PubMed:14722611)
12. Marchio S et al. (2004) Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell, 5:151-62. (PubMed:14998491)
13. Marneros AG et al. (2005) Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol, 167:1451-9. (PubMed:16251428)
14. Martin R et al. (2004) SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis. Development, 131:693-702. (PubMed:14729577)
15. Milosevic J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J Neurosci, 27:412-21. (PubMed:17215402)
16. Muller SM et al. (2005) Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc Natl Acad Sci U S A, 102:10587-92. (PubMed:16027358)
17. Novitskiy SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood, 112:1822-31. (PubMed:18559975)
18. Roberts AE et al. (2007) Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary. Biol Reprod, 76:218-23. (PubMed:17050862)
19. Rolny C et al. (2005) Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling. Exp Cell Res, 308:381-93. (PubMed:15919073)
20. Rossiter H et al. (2007) Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function. FASEB J, 21:3994-4004. (PubMed:17625068)
21. Thurston G et al. (1999) Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science, 286:2511-4. (PubMed:10617467)
22. van den Akker NM et al. (2008) Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovasc Res, 78:366-75. (PubMed:18093989)
23. Vieira JM et al. (2007) Selective requirements for NRP1 ligands during neurovascular patterning. Development, 134:1833-43. (PubMed:17428830)
24. Wu JA et al. (2008) Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol Reprod, 79:1054-61. (PubMed:18753609)
25. Zelzer E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development, 131:2161-71. (PubMed:15073147)
26. Zhao L et al. (2005) Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech Dev, 122:877-86. (PubMed:15927453)
27. Zheng H et al. (2003) The transcription factor Net regulates the angiogenic switch. Genes Dev, 17:2283-97. (PubMed:12975317)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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