Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mpz. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies. [provided by RefSeq, Apr 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Mpz has been shown to bind to the gene products of Kcnma1. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mpz
  • participates in the following biological processes:
    • cell-cell junction maintenance ^[2]

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Summary text based on GO annotations supported by structural data

• Mpz encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin V-set, Immunoglobulin V-set, subgroup, Immunoglobulin-like domain, Immunoglobulin-like fold, Myelin P0 protein, Myelin P0 protein, conserved site, Myelin-PO, C-terminal, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mpz indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Kathiresan T et al. (2009) A protein interaction network for the large conductance Ca2+-activated K+ channel in the mouse cochlea. Mol Cell Proteomics, null:null. (PubMed:19423573)
2. Menichella DM et al. (2001) Protein zero is necessary for E-cadherin-mediated adherens junction formation in Schwann cells. Mol Cell Neurosci, 18:606-18. (PubMed:11749037)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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