Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables sodium:potassium:chloride symporter activity. Acts upstream of or within kidney development and urea transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system and urinary system. Used to study Bartter disease type 1. Human ortholog(s) of this gene implicated in Bartter disease and Bartter disease type 1. Orthologous to human SLC12A1 (solute carrier family 12 member 1).