Automated description from the Alliance of Genome Resources
Exhibits sodium:potassium:chloride symporter activity. Involved in several processes, including cellular hyperosmotic salinity response; excretion; and positive regulation of calcineurin-NFAT signaling cascade. Localizes to the apical plasma membrane. Used to study Bartter disease type 1. Human ortholog(s) of this gene implicated in Bartter disease and Bartter disease type 1. Orthologous to human SLC12A1 (solute carrier family 12 member 1).