About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Uchl1
ubiquitin carboxy-terminal hydrolase L1
MGI:103149

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Uchl1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Chandran AP et al. (1995) Stimulus induced repetitive muscle potentials in the gracile axonal dystrophy (GAD) mouse. Electromyogr Clin Neurophysiol, 35:225-30. (PubMed:7555927)
  2. Guha U et al. (2004) Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development, 131:1175-86. (PubMed:14973275)
  3. Harada T et al. (2004) Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. Am J Pathol, 164:59-64. (PubMed:14695319)
  4. Kameda Y et al. (2002) Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos. Dev Biol, 247:197-209. (PubMed:12074562)
  5. Krasteva G et al. (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A, 108:9478-83. (PubMed:21606356)
  6. Krolewski RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS One, 7:e51737. (PubMed:23284756)
  7. Kurihara LJ et al. (2001) Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum Mol Genet, 10:1963-70. (PubMed:11555633)
  8. Kwon J et al. (2003) Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice. Exp Anim, 52:1-9. (PubMed:12638230)
  9. Loes S et al. (2002) Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers. Anat Embryol (Berl), 205:187-91. (PubMed:12107488)
  10. Miura H et al. (1993) Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy. Neuropathol Appl Neurobiol, 19:41-51. (PubMed:8474599)
  11. Mukoyama M et al. (1989) Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons. Acta Neuropathol (Berl), 79:294-9. (PubMed:2558488)
  12. Oda K et al. (1992) Dying back type axonal degeneration of sensory nerve terminals in muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse. Neuropathol Appl Neurobiol, 18:265-81. (PubMed:1630580)
  13. Osaka H et al. (2003) Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet, 12:1945-58. (PubMed:12913066)
  14. Seta Y et al. (2003) Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. J Comp Neurol, 464:49-61. (PubMed:12866128)
  15. Simpson MT et al. (2001) Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J Neurosci, 21:7089-98. (PubMed:11549719)
  16. Suh JG et al. (1994) Breeding of the gad-mdx mouse: influence of genetically induced denervation on dystrophic muscle fibers. Lab Anim Sci, 44:42-6. (PubMed:8007658)
  17. Vlaskovska M et al. (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci, 21:5670-7. (PubMed:11466438)
  18. Wakisaka S et al. (1996) Protein gene-product 9.5 in developing mouse circumvallate papilla: comparison with neuron-specific enolase and calcitonin gene-related peptide. Anat Embryol (Berl), 194:365-72. (PubMed:8896700)
  19. Yamazaki K et al. (1988) Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse. Proc Soc Exp Biol Med, 187:209-15. (PubMed:3340629)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory