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Gene Ontology Classifications
histocompatibility 2, class II antigen A, beta 1

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GO curators for mouse genes have assigned the following annotations to the gene product of H2-Ab1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Alfonso C et al. (2001) The Impact of H2-DM on Humoral Immune Responses. J Immunol, 167:6348-55. (PubMed:11714799)
  2. Barrera LF et al. (1997) I-A beta gene expression regulation in macrophages derived from mice susceptible or resistant to infection with M. bovis BCG. Mol Immunol, 34:343-55. (PubMed:9244347)
  3. Borras FE et al. (1995) Repression of I-A beta gene expression by the transcription factor PU.1. J Biol Chem, 270:24385-91. (PubMed:7592651)
  4. Celada A et al. (1989) The expression of I-A correlates with the uptake of interferon-gamma by macrophages. Eur J Immunol, 19:205-8. (PubMed:2493384)
  5. Celada A et al. (1996) Identification of a transcription factor that binds to the S box of the I-A beta gene of the major histocompatibility complex. Biochem J, 313:737-44. (PubMed:8611149)
  6. Celada A et al. (1991) IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway. J Immunol, 146:114-20. (PubMed:1845803)
  7. Celada A et al. (1989) Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages. Eur J Immunol, 19:1103-9. (PubMed:2502420)
  8. Cosgrove D et al. (1991) Mice lacking MHC class II molecules. Cell, 66:1051-66. (PubMed:1909605)
  9. Fung-Leung WP et al. (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science, 271:1278-81. (PubMed:8638109)
  10. Karlsson L et al. (1994) Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science, 266:1569-73. (PubMed:7985028)
  11. Kovats S et al. (1998) Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med, 187:245-51. (PubMed:9432982)
  12. Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med, 195:461-72. (PubMed:11854359)
  13. Lemos MP et al. (2003) CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity. J Immunol, 171:5077-84. (PubMed:14607905)
  14. Liljedahl M et al. (1996) HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J, 15:4817-24. (PubMed:8890155)
  15. Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity, 8:233-43. (PubMed:9492004)
  16. Lindstedt R et al. (1995) The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif. Immunity, 3:561-72. (PubMed:7584146)
  17. Martin WD et al. (1996) H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell, 84:543-50. (PubMed:8598041)
  18. Miki N et al. (1992) Role of I-A molecules in early stages of B cell maturation. J Immunol, 149:801-7. (PubMed:1378867)
  19. Miyazaki T et al. (1996) Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell, 84:531-41. (PubMed:8598040)
  20. Ohmura-Hoshino M et al. (2006) Inhibition of MHC class II expression and immune responses by c-MIR. J Immunol, 177:341-54. (PubMed:16785530)
  21. Perraudeau M et al. (2000) Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice Eur J Immunol, 30:2871-80. (PubMed:11069069)
  22. Russell JK et al. (1990) The I-A beta b region (65-85) is a binding site for the superantigen, staphylococcal enterotoxin A. Biochem Biophys Res Commun, 168:696-701. (PubMed:2159298)
  23. Sanderson IR et al. (1993) Differential regulation of B7 mRNA in enterocytes and lymphoid cells. Immunology, 79:434-8. (PubMed:7691725)
  24. Schito ML et al. (1998) Major histocompatibility complex class I- and II-deficient knock-out mice are resistant to primary but susceptible to secondary Eimeria papillata infections. Parasitol Res, 84:394-8. (PubMed:9610637)
  25. Viville S et al. (1993) Mice lacking the MHC class II-associated invariant chain. Cell, 72:635-48. (PubMed:7679955)
  26. Walter W et al. (2001) H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice. J Biol Chem, 276:11086-91. (PubMed:11148202)
  27. Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer, 83:1192-201. (PubMed:11027433)
  28. Yada A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol, 225:21-32. (PubMed:14643301)
  29. Yokota A et al. (2003) Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Microbiol Immunol, 47:285-93. (PubMed:12801066)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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