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Gene Ontology Classifications
Symbol
Name
ID
Stat1
signal transducer and activator of transcription 1
MGI:103063

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Stat1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
References
  1. Aszodi A et al. (2003) Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev, 17:2465-79. (PubMed:14522949)
  2. Collison LW et al. (2012) The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol, 13:290-9. (PubMed:22306691)
  3. Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature, 424:743-8. (PubMed:12872135)
  4. Hou J et al. (2014) Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma. Cancer Cell, 25:49-63. (PubMed:24360797)
  5. Huang YQ et al. (2000) Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. J Biol Chem, 275:6462-8. (PubMed:10692450)
  6. Kim KI et al. (2004) Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol Cell Biol, 24:9592-600. (PubMed:15485925)
  7. Miyamoto H et al. (2012) An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. J Biol Chem, 287:32479-84. (PubMed:22865856)
  8. O'Connell RM et al. (2005) Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. J Immunol, 174:1602-7. (PubMed:15661922)
  9. Tadayoni R et al. (2003) Erythrocyte and leukocyte dynamics in the retinal capillaries of diabetic mice. Exp Eye Res, 77:497-504. (PubMed:12957148)
  10. ten Hoeve J et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol, 22:5662-8. (PubMed:12138178)
  11. Zeng L et al. (2013) Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells. Proteomics, null:null. (PubMed:23749757)
  12. Zhang SS et al. (2003) Expression and activation of STAT proteins during mouse retina development. Exp Eye Res, 76:421-31. (PubMed:12634107)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory