Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of transcription by RNA polymerase II; and protein phosphorylation. Localizes to nucleus. Is expressed in several structures, including axial skeleton; cranium; early conceptus; genitourinary system; and thymus primordium. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; IgA glomerulonephritis; autoimmune hypersensitivity disease (multiple); liver disease (multiple); and systemic scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4).