Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gene expression; interleukin-4-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Part of chromatin. Is expressed in several structures, including 2-cell stage embryo; gut; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lipoid nephrosis; prostate carcinoma; rectum adenocarcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6).