Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Syn2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Syn2
  • is located in the following cellular components:
    • synapse ^[1]
    • synaptic vesicle membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Syn2
  • participates in the following biological processes:
    • neurotransmitter secretion ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Syn2
  • participates in the following biological processes:
    • neurotransmitter secretion based on interactions with Syn1 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Syn2:
  • performs the following molecular functions:
    • calcium-dependent protein binding
  • is located in the following cellular components:
    • synaptic vesicle

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Summary text based on GO annotations supported by structural data

• Syn2 encodes a protein or proteins that contain the following InterPro domains: ATP-grasp fold, subdomain 1, ATP-grasp fold, subdomain 2, Pre-ATP-grasp fold, Synapsin, Synapsin, ATP-binding domain, Synapsin, conserved site, Synapsin, phosphorylation site, Synapsin, pre-ATP-grasp domain, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Syn2 indicates that it:
  • is located in the following cellular components:
    • cell junction

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References

1. Gitler D et al. (2004) Molecular determinants of synapsin targeting to presynaptic terminals. J Neurosci, 24:3711-20. (PubMed:15071120)
2. Rosahl TW et al. (1995) Essential functions of synapsins I and II in synaptic vesicle regulation [see comments] Nature, 375:488-93. (PubMed:7777057)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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