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Gene Ontology Classifications
calcium channel, voltage-dependent, L type, alpha 1C subunit

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cacna1c. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 23, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Balijepalli RC et al. (2006) Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation. Proc Natl Acad Sci U S A, 103:7500-5. (PubMed:16648270)
  2. Campbell DB et al. (1999) L-type calcium channels contribute to the tottering mouse dystonic episodes. Mol Pharmacol, 55:23-31. (PubMed:9882694)
  3. Chopra N et al. (2009) Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A, 106:7636-41. (PubMed:19383796)
  4. Heineke J et al. (2010) CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med, 16:872-9. (PubMed:20639889)
  5. Helton TD et al. (2005) Neuronal L-type calcium channels open quickly and are inhibited slowly. J Neurosci, 25:10247-51. (PubMed:16267232)
  6. Huang G et al. (2006) ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice. J Cell Sci, 119:153-61. (PubMed:16352659)
  7. Huber IG et al. (2004) Opposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels. J Biol Chem, 279:55211-7. (PubMed:15504730)
  8. Krizanova O et al. (1995) Coexpression of skeletal muscle voltage-dependent calcium channel alpha 1 and beta cDNAs in mouse Ltk- cells increases the amount of alpha 1 protein in the cell membrane. Biochem Biophys Res Commun, 211:921-7. (PubMed:7598723)
  9. Leroy J et al. (2011) Phosphodiesterase 4B in the cardiac L-type Ca(2) channel complex regulates Ca(2) current and protects against ventricular arrhythmias in mice. J Clin Invest, 121:2651-61. (PubMed:21670503)
  10. Ma WJ et al. (1992) Expression of a cDNA for a neuronal calcium channel alpha 1 subunit enhances secretion from adrenal chromaffin cells. J Biol Chem, 267:22728-32. (PubMed:1385406)
  11. Ma Y et al. (1995) Cloning and expression of a novel truncated calcium channel from non-excitable cells. J Biol Chem, 270:483-93. (PubMed:7814415)
  12. Moosmang S et al. (2003) Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. EMBO J, 22:6027-34. (PubMed:14609949)
  13. Moosmang S et al. (2005) Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J Neurosci, 25:9883-92. (PubMed:16251435)
  14. Murakami M et al. (2006) Identification of a cardiac isoform of the murine calcium channel alpha1C (Ca(v)1.2-a) subunit and its preferential binding with the beta2 subunit. J Mol Cell Cardiol, 41:115-25. (PubMed:16787652)
  15. Obermair GJ et al. (2004) Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons. Eur J Neurosci, 19:2109-22. (PubMed:15090038)
  16. Schulla V et al. (2003) Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. EMBO J, 22:3844-54. (PubMed:12881419)
  17. Swift F et al. (2012) Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout. Proc Natl Acad Sci U S A, 109:3997-4001. (PubMed:22355118)
  18. Varadi G et al. (1995) Endogenous cardiac Ca2+ channels do not overcome the E-C coupling defect in immortalized dysgenic muscle cells: evidence for a missing link. FEBS Lett, 368:405-10. (PubMed:7635187)
  19. Wegener JW et al. (2004) An essential role of Cav1.2 L-type calcium channel for urinary bladder function. FASEB J, 18:1159-61. (PubMed:15132976)
  20. Wegener JW et al. (2006) Control of intestinal motility by the Ca(v)1.2 L-type calcium channel in mice. FASEB J, 20:1260-2. (PubMed:16636102)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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