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Gene Ontology Classifications
Symbol
Name
ID
Ccr7
chemokine (C-C motif) receptor 7
MGI:103011

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ccr7. (This text reflects annotations as of Thursday, January 16, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol, 173:1682-92. (PubMed:19008373)
  2. Beauvillain C et al. (2011) CCR7 is involved in the migration of neutrophils to lymph nodes. Blood, 117:1196-204. (PubMed:21051556)
  3. Davalos-Misslitz AC et al. (2007) Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice. Blood, 110:4351-9. (PubMed:17785582)
  4. Eppert BL et al. (2010) CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection. Infect Immun, 78:2099-107. (PubMed:20176793)
  5. Forster R et al. (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell, 99:23-33. (PubMed:10520991)
  6. Gomez-Nicola D et al. (2010) CCR7 is expressed in astrocytes and upregulated after an inflammatory injury. J Neuroimmunol, 227:87-92. (PubMed:20638137)
  7. Iijima N et al. (2005) CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells. Int Immunol, 17:1201-12. (PubMed:16027136)
  8. Marsland BJ et al. (2005) CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity, 22:493-505. (PubMed:15845453)
  9. Martin-Cofreces NB et al. (2012) End-binding protein 1 controls signal propagation from the T cell receptor. EMBO J, 31:4140-52. (PubMed:22922463)
  10. Yanagawa Y et al. (2002) CCL19 induces rapid dendritic extension of murine dendritic cells. Blood, 100:1948-56. (PubMed:12200351)
  11. Yanagawa Y et al. (2003) CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities. Blood, 101:4923-9. (PubMed:12609829)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory