Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ptgdr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ptgdr
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway ^[1]
  • performs the following molecular functions:
    • prostaglandin D receptor activity ^[1]
    • prostaglandin J receptor activity ^[1]
  • is located in the following cellular components:
    • plasma membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ptgdr
  • participates in the following biological processes:
    • adenosine metabolic process ^[2]
    • cellular response to prostaglandin D stimulus ^[2]
    • inflammatory response ^[3]
    • male sex determination ^[4]
    • sleep ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ptgdr:
  • participates in the following biological processes:
    • cytosolic calcium ion homeostasis
    • positive regulation of penile erection
    • positive regulation of vasodilation
  • performs the following molecular functions:
    • prostaglandin D receptor activity
  • is located in the following cellular components:
    • membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Ptgdr encodes a protein or proteins that contain the following InterPro domains: GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Prostaglandin D receptor, Prostanoid receptor, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ptgdr indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane

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References

1. Hirai H et al. (2003) Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. Biochem Biophys Res Commun, 307:797-802. (PubMed:12878180)
2. Mizoguchi A et al. (2001) Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A, 98:11674-9. (PubMed:11562489)
3. Takayama K et al. (2005) Thromboxane A(2) and prostaglandin F(2alpha) mediate inflammatory tachycardia. Nat Med, 11:562-6. (PubMed:15834430)
4. Wilhelm D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol, 287:111-24. (PubMed:16185683)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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