Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adcy7. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 17, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Adcy7
  • participates in the following biological processes:
    • cAMP biosynthetic process ^[1]
  • performs the following molecular functions:
    • adenylate cyclase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adcy7:
  • participates in the following biological processes:
    • cAMP biosynthetic process
    • cellular response to ethanol
    • positive regulation of cAMP biosynthetic process
  • performs the following molecular functions:
    • adenylate cyclase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text based on GO annotations supported by structural data

• Adcy7 encodes a protein or proteins that contain the following InterPro domains: Adenylate cyclase-like, Adenylyl cyclase class-3/4/guanylyl cyclase, Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • cyclic nucleotide biosynthetic process
    • intracellular signal transduction
  • performs the following molecular functions:
    • phosphorus-oxygen lyase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adcy7 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • lyase activity
    • metal ion binding
    • nucleotide binding

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References

1. Jiang LI et al. (2008) Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII. J Biol Chem, 283:23429-39. (PubMed:18541530)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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