Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vcan. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Vcan
  • is located in the following cellular components:
    • extracellular region ^[3]
    • proteinaceous extracellular matrix ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Vcan
  • participates in the following biological processes:
    • heart development ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Vcan:
  • participates in the following biological processes:
    • glial cell migration
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Vcan encodes a protein or proteins that contain the following InterPro domains: C-type lectin, C-type lectin fold, C-type lectin, conserved site, C-type lectin-like, Complement control module, EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, Immunoglobulin subtype, Immunoglobulin V-set, Immunoglobulin-like, Immunoglobulin-like fold, Link, Sushi/SCR/CCP, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • performs the following molecular functions:
    • calcium ion binding
    • carbohydrate binding
    • hyaluronic acid binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Vcan indicates that it:
  • performs the following molecular functions:
    • hyaluronic acid binding

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References

1. Mjaatvedt CH et al. (1998) The Cspg2 gene, disrupted in the hdf mutant, is required for right cardiac chamber and endocardial cushion formation. Dev Biol, 202:56-66. (PubMed:9758703)
2. Shibata S et al. (2003) In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage. J Anat, 203:425-32. (PubMed:14620382)
3. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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