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Gene Ontology Classifications
pancreatic and duodenal homeobox 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pdx1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ahlgren U et al. (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/ PDX1-deficient mice. Development, 122:1409-1416. (PubMed:8625829)
  2. Annicotte JS et al. (2003) Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol, 23:6713-24. (PubMed:12972592)
  3. Chu K et al. (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes, 54:1064-73. (PubMed:15793245)
  4. Claiborn KC et al. (2010) Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice. J Clin Invest, 120:3713-21. (PubMed:20811152)
  5. Deramaudt TB et al. (2006) The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. J Biol Chem, 281:38385-95. (PubMed:17056599)
  6. Fujitani Y et al. (2006) Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev, 20:253-66. (PubMed:16418487)
  7. Gannon M et al. (2008) pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol, 314:406-17. (PubMed:18155690)
  8. Gerrish K et al. (2004) Conserved transcriptional regulatory domains of the pdx-1 gene. Mol Endocrinol, 18:533-48. (PubMed:14701942)
  9. Hale MA et al. (2005) The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev Biol, 286:225-37. (PubMed:16126192)
  10. Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes, 49:163-76. (PubMed:10868931)
  11. Jepeal LI et al. (2005) Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology, 146:383-91. (PubMed:15486225)
  12. Kataoka K et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem, 277:49903-10. (PubMed:12368292)
  13. Kim YC et al. (2011) RB regulates pancreas development by stabilizing Pdx1. EMBO J, 30:1563-76. (PubMed:21399612)
  14. Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest, 110:1839-47. (PubMed:12488434)
  15. Ku GM et al. (2012) An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet, 8:e1002449. (PubMed:22253604)
  16. Liberzon A et al. (2004) Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1. Nucleic Acids Res, 32:54-64. (PubMed:14704343)
  17. Liu A et al. (2004) Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Mol Cell Biol, 24:4372-83. (PubMed:15121856)
  18. Liu A et al. (2006) Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1. FEBS Lett, 580:6701-6. (PubMed:17126328)
  19. Mojsin M et al. (2010) PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. Biochem J, 425:107-16. (PubMed:19799567)
  20. Rosanas-Urgell A et al. (2005) Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets. Mol Cell Endocrinol, 237:59-66. (PubMed:15888377)
  21. Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci, 23:7084-92. (PubMed:12904469)
  22. Spence JR et al. (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell, 17:62-74. (PubMed:19619492)
  23. Sumazaki R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet, 36:83-7. (PubMed:14702043)
  24. Ueda T et al. (2009) The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion. Mol Cell Biol, 29:5264-76. (PubMed:19651901)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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