Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to contribute to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of apoptotic process; pancreas development; and regulation of transcription by RNA polymerase II. Localizes to nuclear speck. Predicted to colocalize with cytoplasm. Is expressed in several structures, including genitourinary system; gut; liver and biliary system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1).