Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ednrb. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ednrb
  • participates in the following biological processes:
    • enteric nervous system development ^[9]
    • enteric smooth muscle cell differentiation ^[9]
    • G-protein coupled receptor signaling pathway ^[4]
    • melanocyte differentiation ^[6]
    • negative regulation of neuron maturation ^[9]
    • negative regulation of transcription from RNA polymerase II promoter ^[9]
  • performs the following molecular functions:
    • endothelin receptor activity ^[4]
• The gene product of Ednrb has been shown to bind to the gene products of Edn1. ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ednrb
  • participates in the following biological processes:
    • developmental pigmentation ^[8]
    • melanocyte differentiation ^[5]
    • neural crest cell migration ^[7]
    • peripheral nervous system development ^[1]
    • pigmentation ^[5]
    • posterior midgut development ^[1]
    • regulation of blood pressure ^[2]
    • regulation of pH ^[3]
  • performs the following molecular functions:
    • endothelin receptor activity ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Ednrb
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway based on interactions with Gna13 ^[4]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ednrb:
  • participates in the following biological processes:
    • cGMP-mediated signaling
    • elevation of cytosolic calcium ion concentration
    • endothelin receptor signaling pathway
    • enteric nervous system development
    • epithelial fluid transport
    • macrophage chemotaxis
    • melanocyte differentiation
    • negative regulation of apoptotic process
    • negative regulation of cellular protein metabolic process
    • negative regulation of transcription from RNA polymerase II promoter
    • phospholipase C-activating G-protein coupled receptor signaling pathway
    • pigmentation
    • positive regulation of cell proliferation
    • positive regulation of penile erection
    • positive regulation of protein phosphorylation
    • positive regulation of renal sodium excretion
    • positive regulation of urine volume
    • regulation of blood pressure
    • regulation of epithelial cell proliferation
    • regulation of sensory perception of pain
    • response to lipopolysaccharide
    • response to pain
    • sensory perception of pain
    • vasoconstriction
    • vasodilation
    • vein smooth muscle contraction
  • performs the following molecular functions:
    • endothelin receptor activity
    • peptide hormone binding
    • type 1 angiotensin receptor binding
  • is located in the following cellular components:
    • membrane
    • membrane raft
    • nuclear membrane
    • plasma membrane

---

Summary text based on GO annotations supported by structural data

• Ednrb encodes a protein or proteins that contain the following InterPro domains: Endothelin B receptor, Endothelin receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ednrb indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane

---

References

1. Kapur RP et al. (1995) Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts. Development, 121:3787-95. (PubMed:8582288)
2. Kuwaki T et al. (1999) Endothelin in the central control of cardiovascular and respiratory functions. Clin Exp Pharmacol Physiol, 26:989-94. (PubMed:10626068)
3. Laghmani K et al. (2001) Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. J Clin Invest, 107:1563-9. (PubMed:11413164)
4. Liu B et al. (2003) The first inner loop of endothelin receptor type B is necessary for specific coupling to galpha 13. J Biol Chem, 278:2384-7. (PubMed:12441350)
5. Moore KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics, 125:421-30. (PubMed:2379821)
6. Reid K et al. (1996) Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development, 122:3911-9. (PubMed:9012511)
7. Shin MK et al. (1999) The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature, 402:496-501. (PubMed:10591209)
8. Van Raamsdonk CD et al. (2004) Effects of G-protein mutations on skin color. Nat Genet, 36:961-8. (PubMed:15322542)
9. Wu JJ et al. (1999) Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. Development, 126:1161-73. (PubMed:10021336)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---